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pentobarbital will decrease the extent or effect of amlodipine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.pentobarbital will reduce the level or effect of ibuprofen by influencing hepatic enzyme CYP2C9/ten metabolism. Insignificant/Importance Not known.pentobarbital decreases amounts of vandetanib by affecti